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Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles
Masatoshi Ichihara, Sayaka Sobue, Mikako Ito, Masafumi Ito, Masaaki Hirayama & Kinji Ohno
Medical Gas Research, 2015, Volume 5, Article 12
Effects of 7-day intake of hydrogen-rich water on physical performance of trained and untrained subjects
Rafael Timón, Guillermo Olcina, Adrian González-Custodio, Marta Camacho-Cardenosa, Alba Camacho-Cardenosa, Ismael Martínez Guardado
Biology of Sport, 2021, 38(2), 269–275
Effects of pre-exercise H2 inhalation on physical fatigue and related prefrontal cortex activation during and after high-intensity exercise
Yinglu Hong, Gengxin Dong, Qian Li, Vienna Wang, Meng Liu, Guole Jiang, Dapeng Bao, Junhong Zhou
Frontiers in Physiology, Sec. Exercise Physiology, 2022, Volume 13 (02.09.2022)
Molecular Hydrogen Mitigates Performance Decrement during Repeated Sprints in Professional Soccer Players
Michal Botek, Deepesh Khanna, Jakub Krejčí, Michal Valenta, Andrew McKune, Barbora Sládečková, Iva Klimešová
Nutrients, 2022, 14(3), 508
Hydrogen-Rich Water Supplementation and Up-Hill Running Performance: Effect of Athlete Performance Level
Michal Botek, Jakub Krejčí, Andrew J McKune, Barbora Sládečková
International Journal of Sports Physiology and Performance, 2020, 15, 1193-1196
Effects of hydrogen rich water on prolonged intermittent exercise
Alessandro Da Ponte, Nicola Giovanelli, Daniele Nigris, Stefano Lazzer
The Journal of Sports Medicine and Physical Fitness, May 2018, 58(5), 612-21
Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes
Kosuke Aoki, Atsunori Nakao, Takako Adachi, Yasushi Matsui, Shumpei Miyakawa
Medical Gas Research, 2012, Volume 2, Article 12
Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes: Evidence from a Pilot Study
Gengxin Dong, Jiahui Fu, Dapeng Bao, Junhong Zhou
International Journal of Environmental Research and Public Health, 2022, 19(9), 5413
Hydrogen Rich Water Improved Ventilatory, Perceptual and Lactate Responses to Exercise
Michal Botek, Jakub Krejčí, Andrew J McKune, Barbora Sládečková, Nenad Naumovski
International Journal of Sports Medicine, 2019, 40(14), 879-885
Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and Alleviates Delayed Onset of Muscle Soreness After Resistance Training
Michal Botek, Jakub Krejčí, Andrew McKune, Michal Valenta, Barbora Sládečková
Journal of Strength and Conditioning Research, October 2022, 36(10), 2792-2799
Molecular hydrogen in sports medicine: new therapeutic perspectives
S M Ostojic
International Journal of Sports Medicine, 2015, 36(04), 273-279
Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries
Sergej M Ostojic, Boris Vukomanovic, Julio Calleja-Gonzalez, Jay R Hoffman
Postgraduate Medicine, 2014, Volume 126, Issue 5
Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial
Dejan Javorac, Valdemar Stajer, Laszlo Ratgeber, Andras Olah, Jozsef Betlehem, Pongras Acs, Boris Vukomanovic, Sergej M Ostojic
Research in Sports Medicine, 2021, 29(6), 517-525
The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis
Nikola Todorovic, Julen Fernández-Landa, Asier Santibañez, Branislav Kura, Valdemar Stajer, Darinka Korovljev, Sergej M Ostojic
Pharmaceuticals, 2023, 16(2), 142
A basic study on molecular hydrogen (H2) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H2 level
Hirohisa Ono, Yoji Nishijima, Naoto Adachi, Masaki Sakamoto, Yohei Kudo, Kumi Kaneko, Atsunori Nakao, Takashi Imaoka
Medical Gas Research, 2012, 2(1), 21
Molecular hydrogen: new antioxidant and anti-inflammatory therapy for rheumatoid arthritis and related diseases
Toru Ishibashi
Current Pharmaceutical Design, 2013, 19(35), 6375–6381
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi, Megumi Watanabe, Kiyomi Nishimaki, Kumi Yamagata, Ken-ichiro Katsura, Yasuo Katayama, Sadamitsu Asoh & Shigeo Ohta
Nature Medicine, 2007, Volume 13, 688–694
Stimulation of human damaged sperm motility with hydrogen molecule
Kumiko Nakata, Naoki Yamashita, Yoshihiro Noda, and Ikuroh Ohsawa
Medical Gas Research, 2015, 5, Article 2
Molecular Hydrogen as a Novel Antioxidant: Overview of the Advantages of Hydrogen for Medical Applications
Shigeo Ohta
Elsevier, Methods in Enzymology, 2015, Volume 555, 289-317
Molecular Hydrogen as a Medical Gas for the Treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Possible Efficacy Based on a Literature Review
Shin-ichi Hirano, Yusuke Ichikawa, Bunpei Sato, Yoshiyasu Takefuji, Fumitake Satoh
Frontiers in Neurology, Sec. Experimental Therapeutics, 2022, Volume 13 (11.04.2022)
Molecular hydrogen stimulates the gene expression of transcriptional coactivator PGC-1α to enhance fatty acid metabolism
Naomi Kamimura, Harumi Ichimiya, Katsuya Iuchi, Shigeo Ohta
Aging and Mechanisms of Disease, 2016, Volume 2, Article 16008
Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study
Bing Liang, Le Shi, Dongyue Du, Hua Li, Ning Yi, Yue Xi, Jianjiao Cui, Ping Li, Hongbin Kang, Mami Noda, Xuejun Sun, Jiankang Liu, Shucun Qin, Jiangang Long
Antioxidants, 2023, 12(6), 1245
Anti-inflammatory properties of molecular hydrogen: investigation on parasite-induced liver inflammation
Gharib Bouchra, Hanna Stéphane, Abdallahi Ould M.S., Lepidi Hubert, Gardette Bernard, De Reggi Max
Comptes Rendus de l'Académie des Sciences - Series III, 2001, 324(8), 719–724
Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases
Kinji Ohno, Mikako Ito, Masatoshi Ichihara, Masafumi Ito
Oxidative Medicine and Cellular Longevity, 2012, Article 353152
Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine
Shigeo Ohta
Elsevier, Pharmacology & Therapeutics, October 2014, Volume 144, 1-11
Clinical Effects of Hydrogen Administration: From Animal and Human Diseases to Exercise Medicine
Garth L. Nicolson, Gonzalo Ferreira de Mattos, Robert Settineri, Carlos Costa, Rita Ellithorpe, Steven Rosenblatt, James La Valle, Antonio Jimenez, Shigeo Ohta
International Journal of Clinical Medicine, 2016, Volume 7, No. 1
Molecular hydrogen a therapeutic antioxidant and beyond
Huang, Lei M.D.
Medical Gas Research 6(4), Oct–Dec 2016, Pages 219-222
Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome
Guohua Song, Min Li, Hui Sang, Liying Zhang, Xiuhong Li, Shutong Yao, Yang Yu, Chuanlong Zong, Yazhuo Xue, Shucun Qin
Elsevier, Journal of Lipid Research, July 2013, Volume 54, Issue 7, 1884-1893
The evolution of molecular hydrogen: a noteworthy potential therapy with clinical significance
Brandon J Dixon, Jiping Tang & John H Zhang
Medical Gas Research, 2013, Volume 3, Article 10
Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals
Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi, Megumi Watanabe, Kiyomi Nishimaki, Kumi Yamagata, Ken-Ichiro Katsura, Yasuo Katayama, Sadamitsu Asoh, Shigeo Ohta
Nature Medicine, 2007, 13(6), 688–694
Hydrogen attenuates postoperative pain through Trx1/ASK1/MMP9 signaling pathway
Juan Li, Shirong Ruan, Jinhui Jia, Qian Li, Rumeng Ji, Li Wan, Xing Yang, Peng Teng, Qilin Peng, Ya‑dan Shi, Pan Yu, Yinbing Pan, Man‑lin Duan, Wen‑Tao Liu, Li Zhang, Liang Hu
Journal of Neuroinflammation, 2023, Volume 20, Article 22
Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: an open-label pilot study
Toru Ishibashi, Bunpei Sato, Mariko Rikitake, Tomoki Seo, Ryosuke Kurokawa, Yuichi Hara, Yuji Naritomi, Hiroshi Hara, Tetsuhiko Nagao
Medical Gas Research, 2012, 2(1), 27
Effect of Hydrogen-Rich Water on Oxidative Stress, Liver Function, and Viral Load in Patients with Chronic Hepatitis B
Chunxiang Xia M.D., Wenwu Liu Ph.D., Dongxiao Zeng B.A., Liyao Zhu B.A., Xiaoli Sun B.A., Xuejun Sun Ph.D.
Clinical and Translational Science, Volume 6, Issue 5 p. 372-375
Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy
Qingxi Yang, Guangdong Ji, Rongtao Pan, Yinghui Zhao, Peng Yan
Molecular and Clinical Oncology, November 2017, 7(5), 891–896
Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision
Sara Franceschelli, Daniela Maria Pia Gatta, Mirko Pesce, Alessio Ferrone, Giuseppe Di Martino, Marta Di Nicola, Maria Anna De Lutiis, Ester Vitacolonna, Antonia Patruno, Alfredo Grilli, Mario Felaco, Lorenza Speranza
Journal of Cellular and Molecular Medicine, Volume 22, Issue 5, 2750-2759
Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases
Kinji Ohno, Mikako Ito, Masatoshi Ichihara, Masafumi Ito
Oxidative Medicine and Cellular Longevity, 2012, 353152
Effects of hydrogen-rich water on aging periodontal tissues in rats
Takaaki Tomofuji, Yuya Kawabata, Kenta Kasuyama, Yasumasa Endo, Toshiki Yoneda, Mayu Yamane, Tetsuji Azuma, Daisuke Ekuni & Manabu Morita
Scientific Reports, 2014, Volume 4, Article 5534
Drinking Hydrogen Water Ameliorated Cognitive Impairment in Senescence-Accelerated Mice
Yeunhwa Gu, Chien-Sheng Huang, Tota Inoue, Takenori Yamashita, Torao Ishida, Ki-Mun Kang, Atsunori Nakao
Journal of Clinical Biochemistry and Nutrition, May 2010, 46(3), 269-76
Molecular hydrogen promotes wound healing by inducing early epidermal stem cell proliferation and extracellular matrix deposition
Pengxiang Zhao, Zheng Dang, Mengyu Liu, Dazhi Guo, Ruiliu Luo, Mingzi Zhang, Fei Xie, Xujuan Zhang, Youbin Wang, Shuyi Pan & Xuemei Ma
Inflammation and Regeneration, 2023, Volume 43, Article 22
Inflation using hydrogen improves donor lung quality by regulating mitochondrial function during cold ischemia phase
Le Duan, Lini Quan, Bin Zheng, Zhe Li, Guangchao Zhang, Mengdi Zhang & Huacheng Zhou
BMC Pulmonary Medicine, 2023, Volume 23, Article 213
H2 generated by fermentation in the human gut microbiome influences metabolism and competitive fitness of gut butyrate producers
Austin Campbell, Kristi Gdanetz, Alexander W. Schmidt & Thomas M. Schmidt
Microbiome, 2023, Volume 11, Article 133
Circulating messenger for neuroprotection induced by molecular hydrogen
Mami Noda, Yuya Uemura, Yusuke Yoshii, Taichi Horita, Shota Takemi, Ichiro Sakata, and Takafumi Sakai
Canadian Journal of Physiology and Pharmacology, 17 May 2019
Mast Cells as a Potential Target of Molecular Hydrogen in Regulating the Local Tissue Microenvironment
Dmitri Atiakshin, Andrey Kostin, Artem Volodkin, Anna Nazarova, Viktoriya Shishkina, Dmitry Esaulenko, Igor Buchwalow, Markus Tiemann, Mami Noda
Pharmaceuticals, 2023, 16(6), 817
Neuroprotective and Preventative Effects of Molecular Hydrogen
Mami Noda, Jiankang Liu, Jiangang Long
Current Pharmaceutical Design, 2021, Volume 27, Issue 5
Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia
Kenji Imai, Tomomi Kotani, Hiroyuki Tsuda, Yukio Mano, Tomoko Nakano, Takafumi Ushida, Hua Li, Rika Miki, Seiji Sumigama, Akira Iwase, Akihiro Hirakawa, Kinji Ohno, Shinya Toyokuni, Hideyuki Takeuchi, Tetsuya Mizuno, Akio Suzumura, Fumitaka Kikkawa
Free Radical Biology and Medicine, February 2016, Volume 91, 154-163
Effect of molecular hydrogen saturated alkaline electrolyzed water on disuse muscle atrophy in gastrocnemius muscle
Ryo Fujita 1, Yoshinori Tanaka, Yasuhiro Saihara, Mitsuya Yamakita, Daisuke Ando, Katsuhiro Koyama
Journal of Physiological Anthropology, 2011, 30(5), 195-201
Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques
Qinyuan Zhu, Yueshen Wu, Yongmei Li, Zihua Chen, Lanting Wang, Hao Xiong, Erhong Dai, Jianhua Wu, Bin Fan, Li Ping, Xiaoqun Luo
Scientific Reports, 2018, 8, 8051
Hydrogen Gas Inhalation Treatment in Acute Cerebral Infarction: A Randomized Controlled Clinical Study on Safety and Neuroprotection
Hirohisa Ono, Yoji Nishijima, Shigeo Ohta, Masaki Sakamoto, Kazunori Kinone, Tohru Horikosi, Mituyuki Tamaki, Hirosi Takeshita, Tomoko Futatuki, Wataru Ohishi, Taichi Ishiguro, Saori Okamoto, Shou Ishii, Hiroko Takanami
Journal of Stroke & Cerebrovascular Diseases, November 2017, 26(11), 2587-2594
